Integrated research facility at fort detrick

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Project Title: Integrated research facility at fort detrick
Project Number: 1ZIDAI009006-01
Project web address: Follow on NIH
Organization: Niaid Extramural Activities, United States
Principal Investigators (PI): Jahrling Peter, US
 
Project Description:
For FY09, the Integrated Research Facility in the Division of Clinical Research has significantly increased the level of research facilitation that it provides. Primarily, this support has been directed to facilitating the biodefense and emerging infectious disease research of the Emerging Viral Pathogens section in the Division of Intramural Research. Project 1: Viral pathogenesis of orthopoxviruses and development of countermeasures against infection: Introduction and Objectives 1) Characterize monkeypox virus infection of nonhuman primates by the intravenous and intrabronchial route. 2) Determine if cowpox virus infection of nonhuman primates could serve as a BSL-2 model of orthopoxvirus infection. 3) Determine the efficacy of mitoxantrone against cowpox virus in vivo. Project 2: Viral pathogenesis of simian hemorrhagic fever virus: Introduction and Objectives 1) To characterize the pathogenesis of simian hemorrhagic fever virus in nonhuman primates. Project 3: Identification of cell-surface receptors of viral entry:1) Identification of cell-surface receptors for NIAID Priority Pathogens.2) Identification of the cell-surface receptor of simian hemorrhagic fever virus.3) Characterization of the role of filoviral secreted glycoproteins in filovirus cell entry.Project 4: Develop methods for medical imaging of infectious disease:1) Development of tracers for orthopox viruses and filoviruses.
 
Project Terms:
animal model biodefense biological cell surface receptors cells centers for disease control and prevention (u.s.) clinical clinical research communicable diseases containment cowpox virus development disease emerging communicable diseases filovirus glycoproteins improved in vivo infection infectious diseases research intramural research intravenous laboratories maryland medical medical imaging medical research methods mission mitoxantrone modeling monkey hemorrhagic disease virus monkeypox virus national institute of allergy and infectious disease nonhuman primate novel orthopoxvirus outcome pathogen pathogenesis patients programs public health medicine (field) research research facility research institute research project grants role route science tool tracer united states united states national institutes of health vaccines viral viral pathogenesis virus virus diseases biodefense - biodefense research biodefense - biodefense research - basic research (genomics and pathogenesis) emerging infectious diseases small pox infectious diseases
Project Title: Integrated research facility at fort detrick
Project Number: 1ZIDAI009006-01
Project web address: Follow on NIH
Organization: Niaid Extramural Activities, United States
Principal Investigators (PI): Jahrling Peter, US
 
Project Categories:
Natural Sciences
 
Other Information:
Fiscal Year: 2009
Project Start Date: 1 January 2009
Project End Date: 31 December 2009
 
Project Funding Information:
Funding Mechanism: Intramural Research
Year Funding Organization Total Funding, $
2009 NIH - National Institute Of Allergy And Infectious Diseases $34,269,307
Project Title: Integrated research facility at fort detrick
Project Number: 1ZIDAI009006-01
Project web address: Follow on NIH
Organization: Niaid Extramural Activities, United States
Principal Investigators (PI): Jahrling Peter, US
 
Title FY Funding
There are no results for this project in database.
Project Title: Integrated research facility at fort detrick
Project Number: 1ZIDAI009006-01
Project web address: Follow on NIH
Organization: Niaid Extramural Activities, United States
Principal Investigators (PI): Jahrling Peter, US
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: Integrated research facility at fort detrick
Project Number: 1ZIDAI009006-01
Project web address: Follow on NIH
Organization: Niaid Extramural Activities, United States
Principal Investigators (PI): Jahrling Peter, US
 
Title Journal Year Country Rel
Polyamines and Hypusination Are Required for Ebolavirus Gene Expression and Replication. MBio 2016 united states
An Inactivated Rabies Virus-Based Ebola Vaccine, FILORAB1, Adjuvanted With Glucopyranosyl Lipid A in Stable Emulsion Confers Complete Protection in Nonhuman Primate Challenge Models. J Infect Dis 2016 united states
Biochemical and biophysical characterization of cell-free synthesized Rift Valley fever virus nucleoprotein capsids enables in vitro screening to identify novel antivirals. Biol Direct 2016 england
Divergent Simian Arteriviruses Cause Simian Hemorrhagic Fever of Differing Severities in Macaques. MBio 2016 united states
Human polyclonal immunoglobulin G from transchromosomic bovines inhibits MERS-CoV in vivo. Sci Transl Med 2016 united states
Exposure of rhesus monkeys to cowpox virus Brighton Red by large-particle aerosol droplets results in an upper respiratory tract disease. J Gen Virol 2016 england
3B11-N, a monoclonal antibody against MERS-CoV, reduces lung pathology in rhesus monkeys following intratracheal inoculation of MERS-CoV Jordan-n3/2012. Virology 2016 united states
Natural History of Aerosol Exposure with Marburg Virus in Rhesus Macaques. Viruses 2016 switzerland
Specific Detection of Two Divergent Simian Arteriviruses Using RNAscope In Situ Hybridization. PLoS One 2016 united states