The baltimore longitudinal study of aging

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Project Title: The baltimore longitudinal study of aging
Project Number: 1ZIAAG000015-58
Project web address: Follow on NIH
Organization: Aging NI, United States
Principal Investigators (PI): Studenski Stephanie, US
 
Project Description:
The Baltimore Longitudinal Study of Aging (BLSA), the major research program on human aging supported by the Intramural Research Program of the NIA, was established in 1958 and conducted at the Gerontology Research Center through 2003. Beginning in 2003 a new research unit was established at Harbor Hospital (Baltimore). The study continues to represent a consortium of scientists who work collaboratively to characterize normal and pathological aging. The current team of researchers directing the BLSA has implemented major changes in its design and assessment technology. The primary scientific goals remain consistent with the original BLSA legacy to: 1) identify age-associated differences among individuals that are not explained by diseases and 2) characterize factors that affect transitions from normal to pathological aging. New measures have and continue to be implemented aimed at gaining a better understanding of the effect of age and diseases on the process that leads to mobility disability and poor quality of life in many older adults. Using an integrative and multidisciplinary approach, the study aims to identify and delineate the compensatory mechanisms that occur at multiple levels (cells, tissues, organs, whole body, society) that allow many older persons to maintain a high level of mobility, in spite of multiple pathological processes. The study population consists of a cohort of volunteers followed for life over multiple follow-up visits. Many participants have been enrolled in the study for over 20 years, and some for as long as 50 years. The study is currently enrolling individuals 80 years and older who are extremely well-functioning and have exceptional health. This new aspect of the BLSA has been named The IDEAL (Insight into the Determinants of Exceptional Aging and Longevity) Study. Historically, the BLSA has been the gold-standard reference for aging-related changes in multiple systems. Important findings in cardiovascular function over the life course, factors affecting risk of prostate cancer, age-associated decline in cognitive function, glucose metabolism, muscle strength and bone integrity continue to be published in the present day. Some research goals will be pursued by conducting, in parallel, ancillary studies limited to defined subsets of participants and designed to address pre-formulated hypotheses with the objective of providing information more directly applicable to clinical medicine. The structure of the current BLSA design is based on three levels of measurement: 1. The reference outcome measures are physical and cognitive function. All other measures, directly or indirectly, are aimed at understanding the mechanisms by which old age is associated with high risk of developing mobility disability and impaired cognitive function. Accordingly, the BLSA collects an extensive set of measures on many different aspects of physical and cognitive function; 2. The intermediate level includes measures of anatomical integrity and functionality of the physiological systems important for mobility: central nervous system, peripheral nervous system, muscle, bone and joints, delivery of substances important for energy production, sensory systems that provide feedback from the environment; 3. The third level includes the physiological systems important for maintaining a stable biological homeostasis and include measures of immune function, hormones, oxidative stress/antioxidants, autonomic nervous system, nutritional intake, and physical activity. The overarching hypothesis is that dysfunction of the systems that maintain biological homeostasis is the primary cause of age-associated decline in physical function and development of frailty. Considerable resources have been dedicated to restructuring, documentation and cleaning the data collected over the last 56 years. This project is already in an advanced stage of development and producing important results concerning clinical features for the diagnosis and prognosis of prostate cancer, secular trends in WBC, body weight, muscular strength and their relationship with mortality over the last half of the century and genetic traits associated with accelerated decline in physical function. An essential part of this plan is the inventory, classification and quality control of the entire collection of biological specimens (urine, blood, serum, plasma, red blood cells, etc) collected in BLSA participants during the entire course of the study. In addition, a wide genome scan (Illumina 550K) has been performed in over 1450 participants with available DNA. Using the rich collection of phenotypes collected over many years and the Illumina genotypes, the BLSA has contributed data to several genetic consortia examining the contribution of genetic variability to different human phenotypes, such as blood pressure, circulating lipids, uric acid, pro-inflammatory markers and many others. In addition, we are starting new work on gene-environment interactions. An important sub-project consists of a newly recruited cohort of exceptionally healthy older persons (IDEAL), examining the cross-sectional characteristics of this group compared to the general population, and measuring several physiological parameters that may be directly or indirecly connected with physical and cognitive function. From this prospective, the future plan for the BLSA is to become a permanent laboratory of physiology that studies the different physiological changes that occur over the aging process, with the final aim of understanding their inter-relationships and describing the mechanisms by which they contribute to maintenance of homeostatic equilibrium. Since many BLSA participants who become sick and disabled were often unable to come to the Baltimore clinic for a traditional visit in the clinic creating a severe ascertainment bias informative censoring) in the study of age-related outcome the BLSA has started a home visit project aimed at collecting information from individuals that are no longer able to come to the Baltimore Clinic for their traditional visit. This portion of the project is handled through a R&D contract mechanism described in another report.
 
Project Terms:
address affect age age effect age related aging aging-related process ancillary study antioxidants autonomic nervous system baltimore base biological blood pressure body weight bone cardiovascular physiology cells characteristics classification clinic clinical clinical medicine cognitive cognitive function cohort cohort studies collection contracts data design development diagnosis disability disabled persons disease dna documentation elderly enrollment environment equilibrium equipment and supply inventories erythrocytes feedback follow-up frailty functional disorder functional status future gene environment interaction general population genetic genome scan genotype gerontology glucose metabolism goals gold health health status high risk home visitation homeostasis hormones hospitals house call human immune function improved individual inflammatory marker insight intake interdisciplinary approach intramural research program joints laboratories life life cycle stages lipids longevity longitudinal studies maintenance malignant neoplasm of prostate measurement measures mortality muscle muscle strength names neuraxis normal aging nutritional organ outcome outcome forecast outcome measure oxidative stress participant pathologic processes pathological aging peripheral nervous system phenotype physical activity physical function physiological physiology plasma process production programs prospective publishing quality control quality of life recruitment activity reference standards reporting research research and development research personnel resources risk scientist sensory system serum societies specimen staging structure study population system technology assessment time tissues trait trend uric acid urine visit volunteer work clinical research
Project Title: The baltimore longitudinal study of aging
Project Number: 1ZIAAG000015-58
Project web address: Follow on NIH
Organization: Aging NI, United States
Principal Investigators (PI): Studenski Stephanie, US
 
Project Categories:
Natural Sciences
 
Other Information:
Fiscal Year: 2016
Project Start Date: 1 January 2015
Project End Date: 31 December 2016
 
Project Funding Information:
Funding Mechanism: Intramural Research
Year Funding Organization Total Funding, $
2016 NIH - National Institute On Aging $12,293,001
Project Title: The baltimore longitudinal study of aging
Project Number: 1ZIAAG000015-58
Project web address: Follow on NIH
Organization: Aging NI, United States
Principal Investigators (PI): Studenski Stephanie, US
 
Title FY Funding
There are no results for this project in database.
Project Title: The baltimore longitudinal study of aging
Project Number: 1ZIAAG000015-58
Project web address: Follow on NIH
Organization: Aging NI, United States
Principal Investigators (PI): Studenski Stephanie, US
 
Project Title Organization FY Funding
The Baltimore Longitudinal Study Of AgingAging NI2016$12,293,001
The Baltimore Longitudinal Study Of AgingAging NI2015$9,174,649
Project Title: The baltimore longitudinal study of aging
Project Number: 1ZIAAG000015-58
Project web address: Follow on NIH
Organization: Aging NI, United States
Principal Investigators (PI): Studenski Stephanie, US
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: The baltimore longitudinal study of aging
Project Number: 1ZIAAG000015-58
Project web address: Follow on NIH
Organization: Aging NI, United States
Principal Investigators (PI): Studenski Stephanie, US
 
Title Journal Year Country Rel
Midlife and Late-Life Cardiorespiratory Fitness and Brain Volume Changes in Late Adulthood: Results From the Baltimore Longitudinal Study of Aging. J Gerontol A Biol Sci Med Sci 2016 united states
Apical periodontitis and incident cardiovascular events in the Baltimore Longitudinal Study of Ageing. Int Endod J 2016 england
Overall Cardiovascular Health Is Associated With All-Cause and Cardiovascular Disease Mortality Among Older Community-Dwelling Men and Women. J Aging Health 2016 united states
Association between Both Total Baseline Urinary and Dietary Polyphenols and Substantial Physical Performance Decline Risk in Older Adults: A 9-year Follow-up of the InCHIANTI Study. J Nutr Health Aging 2016 france
Association Between Accelerated Multimorbidity and Age-Related Cognitive Decline in Older Baltimore Longitudinal Study of Aging Participants without Dementia. J Am Geriatr Soc 2016 united states
The effect of age and microstructural white matter integrity on lap time variation and fast-paced walking speed. Brain Imaging Behav 2016 united states
Fatigued, but Not Frail: Perceived Fatigability as a Marker of Impending Decline in Mobility-Intact Older Adults. J Am Geriatr Soc 2016 united states
Ankle Proprioception-Associated Gait Patterns in Older Adults: Results from the Baltimore Longitudinal Study of Aging. Med Sci Sports Exerc 2016 united states
Individual estimates of age at detectable amyloid onset for risk factor assessment. Alzheimers Dement 2016 united states
Motoric Cognitive Risk Syndrome and Falls Risk: A Multi-Center Study. J Alzheimers Dis 2016 netherlands
Cross-Sectional and Longitudinal Associations Between Adiposity and Walking Endurance in Adults Age 60-79. J Gerontol A Biol Sci Med Sci 2016
Lower gray matter integrity is associated with greater lap time variation in high-functioning older adults. Exp Gerontol 2016 england
Sleep Duration and Subsequent Cortical Thinning in Cognitively Normal Older Adults. Sleep 2016 united states
SARC-F: a symptom score to predict persons with sarcopenia at risk for poor functional outcomes. J Cachexia Sarcopenia Muscle 2016 germany
Plasma Biomarkers of Poor Muscle Quality in Older Men and Women from the Baltimore Longitudinal Study of Aging. J Gerontol A Biol Sci Med Sci 2016 united states
Peripheral sphingolipids are associated with variation in white matter microstructure in older adults. Neurobiol Aging 2016 united states
Impaired Vestibular Function and Low Bone Mineral Density: Data from the Baltimore Longitudinal Study of Aging. J Assoc Res Otolaryngol 2016
State- and trait-dependent associations of vitamin-D with brain function during aging. Neurobiol Aging 2016 united states
Ankle proprioceptive acuity is associated with objective as well as self-report measures of balance, mobility, and physical function. Age (Dordr) 2016 netherlands
Bioavailable Testosterone Linearly Declines Over A Wide Age Spectrum in Men and Women From The Baltimore Longitudinal Study of Aging. J Gerontol A Biol Sci Med Sci 2016 united states
Circulating ceramides are inversely associated with cardiorespiratory fitness in participants aged 54-96 years from the Baltimore Longitudinal Study of Aging. Aging Cell 2016 england
Rising Energetic Cost of Walking Predicts Gait Speed Decline With Aging. J Gerontol A Biol Sci Med Sci 2016 united states
Image-Based Tissue Distribution Modeling for Skeletal Muscle Quality Characterization. IEEE Trans Biomed Eng 2016 united states
31P Magnetic Resonance Spectroscopy Assessment of Muscle Bioenergetics as a Predictor of Gait Speed in the Baltimore Longitudinal Study of Aging. J Gerontol A Biol Sci Med Sci 2016 united states
Sex-specific age associations of ankle proprioception test performance in older adults: results from the Baltimore Longitudinal Study of Aging. Age Ageing 2015 england
Quantifying the lifetime circadian rhythm of physical activity: a covariate-dependent functional approach. Biostatistics 2015 england
Lap time variation and executive function in older adults: the Baltimore Longitudinal Study of Aging. Age Ageing 2015 england
Thyroid Hormone Therapy and Risk of Thyrotoxicosis in Community-Resident Older Adults: Findings from the Baltimore Longitudinal Study of Aging. Thyroid 2015 united states
Age-associated telomere attrition of lymphocytes in vivo is co-ordinated with changes in telomerase activity, composition of lymphocyte subsets and health conditions. Clin Sci (Lond) 2015 england
Demographic and clinical variables affecting mid- to late-life trajectories of plasma ceramide and dihydroceramide species. Aging Cell 2015
Factors affecting longitudinal trajectories of plasma sphingomyelins: the Baltimore Longitudinal Study of Aging. Aging Cell 2015 england
Changes in A? biomarkers and associations with APOE genotype in 2 longitudinal cohorts. Neurobiol Aging 2015 united states
Vitamin D deficiency and airflow limitation in the Baltimore Longitudinal Study of Ageing. Eur J Clin Invest 2015 england
Association between saccular function and gait speed: data from the Baltimore Longitudinal Study of Aging. Otol Neurotol 2015 united states
Renal function and long-term decline in cognitive function: the Baltimore Longitudinal Study of Aging. Am J Nephrol 2015 switzerland
The Pittsburgh Fatigability scale for older adults: development and validation. J Am Geriatr Soc 2015 united states
Epidemiology of vestibulo-ocular reflex function: data from the Baltimore Longitudinal Study of Aging. Otol Neurotol 2015 united states
Hyperglycemia predicts persistently lower muscle strength with aging. Diabetes Care 2015 united states
Sex-specific differences in progressive glucose intolerance and hip geometry: the Baltimore Longitudinal Study of Aging. Osteoporos Int 2015 england
Gait characteristics associated with walking speed decline in older adults: results from the Baltimore Longitudinal Study of Aging. Arch Gerontol Geriatr 2015 netherlands
Gait energetic efficiency in older adults with and without knee pain: results from the Baltimore Longitudinal Study of Aging. Age (Dordr) 2015 netherlands
Adipose tissue density, a novel biomarker predicting mortality risk in older adults. J Gerontol A Biol Sci Med Sci 2014 united states
GeMes, clusters of DNA methylation under genetic control, can inform genetic and epigenetic analysis of disease. Am J Hum Genet 2014 united states
Trajectories of physiological dysregulation predicts mortality and health outcomes in a consistent manner across three populations. Mech Ageing Dev 2014 ireland
Multilocus genetic risk score associates with ischemic stroke in case-control and prospective cohort studies. Stroke 2014 united states
Assessing the physical cliff: detailed quantification of age-related differences in daily patterns of physical activity. J Gerontol A Biol Sci Med Sci 2014 united states
Caffeine and alcohol intakes and overall nutrient adequacy are associated with longitudinal cognitive performance among U.S. adults. J Nutr 2014 united states
Estimating energy expenditure from heart rate in older adults: a case for calibration. PLoS One 2014 united states
Difference in muscle quality over the adult life span and biological correlates in the Baltimore Longitudinal Study of Aging. J Am Geriatr Soc 2014 united states
Energy Metabolism and the Burden of Multimorbidity in Older Adults: Results From the Baltimore Longitudinal Study of Aging. J Gerontol A Biol Sci Med Sci 2014
Prevalence, clinical correlates, and functional impact of subaortic ventricular septal bulge (from the Baltimore Longitudinal Study of Aging). Am J Cardiol 2014 united states
GIP contributes to islet trihormonal abnormalities in type 2 diabetes. J Clin Endocrinol Metab 2014 united states
A new roadmap for drug development for Alzheimer's disease. Nat Rev Drug Discov 2014 england
Impact of central obesity on the estimation of carotid-femoral pulse wave velocity. Am J Hypertens 2014 united states
Trans-ethnic meta-analysis of white blood cell phenotypes. Hum Mol Genet 2014 england
Cardiorespiratory fitness and accelerated cognitive decline with aging. J Gerontol A Biol Sci Med Sci 2014 united states
Trajectories of Alzheimer disease-related cognitive measures in a longitudinal sample. Alzheimers Dement 2014 united states
Role of bone mineral density in the inverse relationship between body size and aortic calcification: results from the Baltimore Longitudinal Study of Aging. Atherosclerosis 2014 ireland
Validation Study of the Body Adiposity Index as a Predictor of Percent Body Fat in Older Individuals: Findings From the BLSA. J Gerontol A Biol Sci Med Sci 2014 united states
Association of hearing impairment with brain volume changes in older adults. Neuroimage 2014 united states
IDEAL aging is associated with lower resting metabolic rate: the Baltimore Longitudinal Study of Aging. J Am Geriatr Soc 2014 united states
The association between leptin and depressive symptoms is modulated by abdominal adiposity. Psychoneuroendocrinology 2014 england
Cross-population validation of statistical distance as a measure of physiological dysregulation during aging. Exp Gerontol 2014 england
Six-minute walk is a better outcome measure than treadmill walking tests in therapeutic trials of patients with peripheral artery disease. Circulation 2014 united states
Genetic association study of QT interval highlights role for calcium signaling pathways in myocardial repolarization. Nat Genet 2014 united states
Lipid peroxidation and depressed mood in community-dwelling older men and women. PLoS One 2013 united states
Ischemic stroke is associated with the ABO locus: the EuroCLOT study. Ann Neurol 2013 united states
Effect of complement CR1 on brain amyloid burden during aging and its modification by APOE genotype. Biol Psychiatry 2013 united states
Computer-aided assessment of regional abdominal fat with food residue removal in CT. Acad Radiol 2013 united states
Glomerular filtration rate equations overestimate creatinine clearance in older individuals enrolled in the Baltimore Longitudinal Study on Aging: impact on renal drug dosing. Pharmacotherapy 2013 united states
Personality, metabolic rate and aerobic capacity. PLoS One 2013 united states
Self-reported sleep and *-amyloid deposition in community-dwelling older adults. JAMA Neurol 2013 united states
Relationship between vitamin D status and left ventricular geometry in a healthy population: results from the Baltimore Longitudinal Study of Aging. J Intern Med 2013 england
Alzheimer risk variant CLU and brain function during aging. Biol Psychiatry 2013 united states
Selective contribution of regional adiposity, skeletal muscle, and adipokines to glucose disposal in older adults. J Am Geriatr Soc 2012 united states
Automated quantification of muscle and fat in the thigh from water-, fat-, and nonsuppressed MR images. J Magn Reson Imaging 2012 united states
Alcohol consumption and premotor corpus callosum in older adults. Eur Neuropsychopharmacol 2012 netherlands
Baseline cardiovascular risk predicts subsequent changes in resting brain function. Stroke 2012 united states
Associations between personality traits, physical activity level, and muscle strength. J Res Pers 2012
Personality typology in relation to muscle strength. Int J Behav Med 2012 england
Carotid atherosclerosis and prospective risk of dementia. Stroke 2012 united states
The role of energetic cost in the age-related slowing of gait speed. J Am Geriatr Soc 2012 united states
Are myocardial infarction--associated single-nucleotide polymorphisms associated with ischemic stroke? Stroke 2012 united states
Patterns of regional cerebral blood flow associated with low hemoglobin in the Baltimore Longitudinal Study of Aging. J Gerontol A Biol Sci Med Sci 2012 united states
Longitudinal imaging pattern analysis (SPARE-CD index) detects early structural and functional changes before cognitive decline in healthy older adults. Neurobiol Aging 2012 united states
Five-factor personality traits and age trajectories of self-rated health: the role of question framing. J Pers 2012 united states
Age-associated gait patterns and the role of lower extremity strength - results from the Baltimore Longitudinal Study of Aging. Arch Gerontol Geriatr 2012 netherlands
Memory shaped by age stereotypes over time. J Gerontol B Psychol Sci Soc Sci 2012 united states
Correspondence between in vivo (11)C-PiB-PET amyloid imaging and postmortem, region-matched assessment of plaques. Acta Neuropathol 2012 germany
Framingham risk score and alternatives for prediction of coronary heart disease in older adults. PLoS One 2012 united states
Use of the Frank-Starling mechanism during exercise is linked to exercise-induced changes in arterial load. Am J Physiol Heart Circ Physiol 2012 united states
Glucose and insulin measurements from the oral glucose tolerance test and relationship to muscle mass. J Gerontol A Biol Sci Med Sci 2012 united states
Plasma clusterin concentration is associated with longitudinal brain atrophy in mild cognitive impairment. Neuroimage 2012 united states
Validity of self-reported history of endodontic treatment in the Baltimore Longitudinal Study of Aging. J Endod 2012 united states
Thyroid function and prevalent and incident metabolic syndrome in older adults: the Health, Ageing and Body Composition Study. Clin Endocrinol (Oxf) 2012 england
Common variants at 6p21.1 are associated with large artery atherosclerotic stroke. Nat Genet 2012 united states
Aging and the energetic cost of life. J Am Geriatr Soc 2012 united states
Plasma BDNF is associated with age-related white matter atrophy but not with cognitive function in older, non-demented adults. PLoS One 2012 united states
Arterial stiffness and vitamin D levels: the Baltimore longitudinal study of aging. J Clin Endocrinol Metab 2012 united states
Impulsivity-related traits are associated with higher white blood cell counts. J Behav Med 2012 united states