Consortium for alzheimers sequence analysis (casa)

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Project Title: Consortium for alzheimers sequence analysis (casa)
Project Number: 1UF1AG047133-01
Project web address: Follow on NIH
Organization: University Of Pennsylvania, United States, Pennsylvania, PHILADELPHIA
Principal Investigators (PI): Schellenberg Gerard David, US
Pericak-Vance Margaret A, US
Farrer Lindsay A, US
Haines Jonathan L, US
Mayeux Richard P, US
 
Project Description:
This proposal, entitled the Consortium for Alzheimer's Sequence Analysis (CASA) describes plans to analyze whole exome and whole genome sequence data generated from subjects with Alzheimer's disease (AD) and elderly normal controls. These data will be generated by the National Human Genome Institute Large-Scale Sequence Program. The goal of the planned analyses is to identify genes that have alleles that protect against or increase susceptibility to AD. This is a multiple PI proposal, a collaboration between five senior AD genetics investigators (Farrer, Haines, Mayeux, Pericak-Vance, Schellenberg). CASA has 4 cores and 3 projects. Core A is the Administrative core that will coordinate all aspects of CASA. Core B is the Analysis Statistics and Innovation core that will design and assist analysis by other cores/projects and devise novel methods of statistical analysis. Core C is that Data Management and Information Transfer Core that will implement analyses designed by Core B and the projects. Core C will provide high-performance computing for CASA. These three cores are mandated by FOA PAR-12-183. Core D is the In Silico Functional Genomics Core that will annotate AD-associated variants and perform pathway and interaction analyses. Project 1 will evaluate variants detected in the sequence data for association with AD to identify protective and susceptibility alleles. Project 2 will evaluate sequence data from multiplex AD families to identify variants associated with AD risk and protection, and evaluate variant co-segregation with AD. Project 3 will focus on structural variants (insertion-deletions, copy number variants, and chromosomal rearrangements). The project will use existing methods and develop and implement novel approaches for detecting structural variants. The projects and cores are highly interdependent. For example, structural variants identified by Project 3 will be integrated with single nucleotide AD-associated variants identified by Projects 1 and 2. Likewise variants identified by Project 1 will be tested in the family-based data sets. Core B will assist all projects in designing analyses and Core C will implement Project analyses. Core D will annotate and help interpret results from all projects.
 
Project Terms:
address affect alleles alzheimer's disease alzheimer's disease risk architecture base boxing candidate disease gene case control chromosomal rearrangement code collaborations complex computer simulation cost cost of illness coupling data data analyses data management data set data storage and retrieval databases deletion analysis design detection disease disease progression elderly endophenotype exome exome sequencing family follow-up functional genomics functional rna genes genetic genetic variant genome sequencing genome wide association study genomics genotype goals haplotypes health high performance computing human genome innovation insertion/deletion mutation institutes interest knowledge large-scale sequencing late onset alzheimer disease location measures methods novel novel strategies nucleotides pathway interactions phenotype predisposition prevent programs proteins quality control rare variant regulatory element research personnel resources response risk running segregation sequence analysis series statistical methods statistics testing transcript variant variation (genetics) aging biotechnology brain disorders clinical research dementia genetics neurodegenerative neurosciences
Project Title: Consortium for alzheimers sequence analysis (casa)
Project Number: 1UF1AG047133-01
Project web address: Follow on NIH
Organization: University Of Pennsylvania, United States, Pennsylvania, PHILADELPHIA
Principal Investigators (PI): Schellenberg Gerard David, US
Pericak-Vance Margaret A, US
Farrer Lindsay A, US
Haines Jonathan L, US
Mayeux Richard P, US
 
Project Categories:
Natural Sciences > Aging Diseases and Pathology > Neurodegenerative diseases > Alzheimer's disease
 
Other Information:
Fiscal Year: 2014
Project Start Date: 15 June 2014
Project End Date: 31 May 2018
Project program: Multi-Year Funded Research Project Cooperative Agreement
 
Project Funding Information:
Funding Mechanism: Non-SBIR/STTR RPGs
Year Funding Organization Total Funding, $
2014 NIH - National Institute On Aging $12,638,607
Project Title: Consortium for alzheimers sequence analysis (casa)
Project Number: 1UF1AG047133-01
Project web address: Follow on NIH
Organization: University Of Pennsylvania, United States, Pennsylvania, PHILADELPHIA
Principal Investigators (PI): Schellenberg Gerard David, US
Pericak-Vance Margaret A, US
Farrer Lindsay A, US
Haines Jonathan L, US
Mayeux Richard P, US
 
Title FY Funding
There are no results for this project in database.
Project Title: Consortium for alzheimers sequence analysis (casa)
Project Number: 1UF1AG047133-01
Project web address: Follow on NIH
Organization: University Of Pennsylvania, United States, Pennsylvania, PHILADELPHIA
Principal Investigators (PI): Schellenberg Gerard David, US
Pericak-Vance Margaret A, US
Farrer Lindsay A, US
Haines Jonathan L, US
Mayeux Richard P, US
 
Project Title Organization FY Funding
Consortium For Alzheimers Sequence Analysis (Casa)University Of Pennsylvania2014$12,638,607
Project Title: Consortium for alzheimers sequence analysis (casa)
Project Number: 1UF1AG047133-01
Project web address: Follow on NIH
Organization: University Of Pennsylvania, United States, Pennsylvania, PHILADELPHIA
Principal Investigators (PI): Schellenberg Gerard David, US
Pericak-Vance Margaret A, US
Farrer Lindsay A, US
Haines Jonathan L, US
Mayeux Richard P, US
 
Project number Project title Principal investigator
There are no any related projects.
Project Title: Consortium for alzheimers sequence analysis (casa)
Project Number: 1UF1AG047133-01
Project web address: Follow on NIH
Organization: University Of Pennsylvania, United States, Pennsylvania, PHILADELPHIA
Principal Investigators (PI): Schellenberg Gerard David, US
Pericak-Vance Margaret A, US
Farrer Lindsay A, US
Haines Jonathan L, US
Mayeux Richard P, US
 
Title Journal Year Country Rel
Pathway analysis by randomization incorporating structure-PARIS: an update. Bioinformatics 2016 england
In Silico Functional Annotation of Genomic Variation. Curr Protoc Hum Genet 2016 united states