Offpsring study of mechanisms for racial disparities in alzheimer's disease

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Project Title: Offpsring study of mechanisms for racial disparities in alzheimer's disease
Project Number: 1RF1AG054070-01
Project web address: Follow on NIH
Organization: Columbia University Health Sciences, United States, New York, NEW YORK
Principal Investigators (PI): Manly Jennifer Jaie, US
Brickman Adam M, US
 
Project Description:
The overall aim of this study is to identify underlying biological and sociocultural mechanisms of racial/ethnic disparities in cognitive function among a middle-aged cohort of 3,000 offspring whose parents do and do not have Alzheimer's Disease (AD). Studies of non-Hispanic Whites have shown that children of people with AD are at increased risk of developing the disease, and that factors such as parental age at onset and APOE allele status may modify risk associated with a family history of AD. Rates of AD are two to three times higher among Hispanic and African American than among non-Hispanic White elders and the prevalence of many cardiovascular and demographic risk factors for AD is higher among ethnic minorities than among non- Hispanic Whites. However, potential mediators and modifiers of family risk have not been well examined among racial and ethnic minorities, nor has much prior work been conducted among families where data from detailed clinical and biomarker examinations on parents were available from in-person examinations. Since pathology begins to manifest in the brain in the fifth and sixth decades of life, we propose that mechanisms for racial/ethnic disparities can be more clearly revealed in middle age and thus help to clarify the determinants and pathways of ethnic disparities in cognitive impairment with aging and potential critical periods for intervention. Our overarching hypothesis is that the primary mode of transmission of parental AD risk among racial/ethnic minorities is via vascular and social pathways, while the primary transmission of parental AD risk among Whites is via genetic pathways that affect amyloid deposition in the brain. Specifically, the project will 1) determine which biological mediators of parental risk of AD on offspring cognition differ most across race/ethnicity, 2) determine which educational, economic, and social moderators of parental risk of AD on offspring cognition differ most across race/ethnicity, and 3) use directly measured parental risk factor data to refine our understanding of mechanisms of racial/ethnic disparities in AD.
 
Project Terms:
abeta deposition accounting address affect african american age aged aging alleles alzheimer's disease alzheimer's disease risk amyloid beta-protein amyloid deposition amyloid imaging biological biological markers blood blood vessels brain brain imaging buffers burden of illness cardiovascular diseases cardiovascular risk factor cardiovascular system caring child clinical biomarkers cognition cognitive function cognitive testing cohort critical period data discrimination disease disease diagnosis disease marker disease transmission disparity reduction economic burden economics education elderly equilibrium ethnic difference ethnic disparity ethnic minority population ethnic origin etiology experience family family history of generations genetic genetic risk health height high risk high school hippocampus (brain) hispanic americans hispanics impaired cognition income intervention life magnetic resonance imaging measures mediating mediator of activation protein medical middle age minority modeling modifiable risk non-genetic not hispanic or latino offspring parental ages parents pathology pathway interactions persons positron-emission tomography pre-clinical prevalence prevent race racial and ethnic racial and ethnic disparities racial minority recruitment activity research response risk risk factors segregation social socioeconomic status staging testing time transmission process vascular diseases washington white matter work acquired cognitive impairment alzheimer's disease including alzheimer's disease related dementias (ad/adrd) basic behavioral and social science behavioral and social science brain disorders cardiovascular clinical research dementia neurodegenerative neurosciences prevention
Project Title: Offpsring study of mechanisms for racial disparities in alzheimer's disease
Project Number: 1RF1AG054070-01
Project web address: Follow on NIH
Organization: Columbia University Health Sciences, United States, New York, NEW YORK
Principal Investigators (PI): Manly Jennifer Jaie, US
Brickman Adam M, US
 
Project Categories:
Natural Sciences > Aging Diseases and Pathology
 
Other Information:
Fiscal Year: 2016
Project Start Date: 1 September 2016
Project End Date: 31 March 2021
Project program: Multi-Year Funded Research Project Grant
 
Project Funding Information:
Funding Mechanism: Non-SBIR/STTR RPGs
Year Funding Organization Total Funding, $
2016 NIH - National Institute On Aging $9,227,171
Project Title: Offpsring study of mechanisms for racial disparities in alzheimer's disease
Project Number: 1RF1AG054070-01
Project web address: Follow on NIH
Organization: Columbia University Health Sciences, United States, New York, NEW YORK
Principal Investigators (PI): Manly Jennifer Jaie, US
Brickman Adam M, US
 
Title FY Funding
There are no results for this project in database.
Project Title: Offpsring study of mechanisms for racial disparities in alzheimer's disease
Project Number: 1RF1AG054070-01
Project web address: Follow on NIH
Organization: Columbia University Health Sciences, United States, New York, NEW YORK
Principal Investigators (PI): Manly Jennifer Jaie, US
Brickman Adam M, US
 
Project Title Organization FY Funding
Offpsring Study Of Mechanisms For Racial Disparities In Alzheimer'S DiseaseColumbia University Health Sciences2016$9,227,171
Project Title: Offpsring study of mechanisms for racial disparities in alzheimer's disease
Project Number: 1RF1AG054070-01
Project web address: Follow on NIH
Organization: Columbia University Health Sciences, United States, New York, NEW YORK
Principal Investigators (PI): Manly Jennifer Jaie, US
Brickman Adam M, US
 
Project number Project title Principal investigator
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Project Title: Offpsring study of mechanisms for racial disparities in alzheimer's disease
Project Number: 1RF1AG054070-01
Project web address: Follow on NIH
Organization: Columbia University Health Sciences, United States, New York, NEW YORK
Principal Investigators (PI): Manly Jennifer Jaie, US
Brickman Adam M, US
 
Title Journal Year Country Rel