Genetic epidemiology of cerebrovascular factors in alzheimer's disease

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Project Title: Genetic epidemiology of cerebrovascular factors in alzheimer's disease
Project Number: 1RF1AG054023-01
Project web address: Follow on NIH
Organization: Columbia University Health Sciences, United States, New York, NEW YORK
Principal Investigators (PI): Mayeux Richard, US
 
Project Description:
PROJECT SUMMARY Clinical criteria for late-onset Alzheimer's disease (LOAD) excludes individuals with ?substantial cerebrovascular disease? but as many as up 70% of patients with LOAD have cerebrovascular pathology in addition to amyloid plaques and neurofibrillary tangles at postmortem examination. Whether cerebrovascular damage represents a cause of LOAD, an additional brain insult or whether cerebrovascular pathology interacts with genetic factors remains unknown. The Washington Heights and Inwood, Columbia Aging Project is a large, epidemiological investigation of dementia in a multi-ethnic community in northern Manhattan, New York. The investigators have estimated the ethnic and sex-specific rates of late onset Alzheimer's disease and mild cognitive impairment, conducted longitudinal assessments of cognitive performance, health and lifestyle factors, mood, ADLs, blood pressure, anthropometry, several blood-based biomarkers, genome wide association studies (GWAS), structural MRI and is in the process of completing whole exome sequencing (WES) in 4100 individuals. We intend to take advantage of this multi-ethnic, longitudinal cohort to test hypotheses concerning how genetic variants, cardiovascular and cerebrovascular risk factors and cerebrovascular disease predispose to LOAD and whether these relationships differ by ethnic group. We intend to address three critical questions: 1) Do genetic variants influence both LOAD and cardio-cerebrovascular risk factors independently or do they interact? 2) Do cardio- cerebrovascular risk factors lead to cerebrovascular pathology, present on brain MRI, which in turn simply lowers the threshold for clinical onset of dementia? 3) Are genetic variants unrelated to cardio-cerebrovascular risk factors and simply exacerbate the effects of cerebrovascular pathology leading to LOAD? Or could the reverse be true, that silent cerebrovascular disease exacerbates the effects of genetic variants on LOAD risk? LOAD and cerebrovascular disease are likely to be part of a continuum in which the onset and clinical manifestations of dementia are jointly determined. Thus, investigating the relationship between genes harboring variants, vascular risk factors, cerebrovascular disease and LOAD would advance our understanding of this complex disease process and will help develop potential targets for treatments or preventive measures that are more precise for the individual patient.
 
Project Terms:
address african american african caribbean aging alzheimer's disease alzheimer's disease risk anthropometry autopsy base bioinformatics blood pressure blood vessels blood-based biomarker brain brain endothelial cell brain imaging cardiovascular diseases cardiovascular system caribbean hispanic case control caucasians cells cerebrovascular cerebrovascular disorders clinical code cognitive performance cohort cohort studies communities complex crispr/cas technology data data set dementia diagnosis differential expression disease dna sequence elderly endothelial cells epidemiology ethnic group event exome sequencing figs - dietary follow-up frequencies functional disorder genes genetic genetic epidemiology genetic transcription genetic variant genome wide association study genome-wide genotype health height human hyperlipidemia hypertension immune function individual individual patient induced mutation induced pluripotent stem cell infarction inflammation investigation late onset alzheimer disease lead lifestyle factors lipids magnetic resonance imaging methods mild cognitive impairment moods mutation neurofibrillary tangles new york novel participant pathology pathway interactions patients pleiotropism precision medicine preventive measure process property proteins research personnel response risk risk factors rna splicing sampling senile plaques sex signal transduction smoking snp array testing tool trait transcript transcriptome sequencing untranslated rna variant vascular diseases washington white matter hyperintensity acquired cognitive impairment alzheimer's disease related dementias (adrd) alzheimer's disease including alzheimer's disease related dementias (ad/adrd) brain disorders cardiovascular clinical research genetics human genome neurodegenerative neurosciences prevention vascular cognitive impairment/dementia
Project Title: Genetic epidemiology of cerebrovascular factors in alzheimer's disease
Project Number: 1RF1AG054023-01
Project web address: Follow on NIH
Organization: Columbia University Health Sciences, United States, New York, NEW YORK
Principal Investigators (PI): Mayeux Richard, US
 
Project Categories:
Natural Sciences > Aging Diseases and Pathology
 
Other Information:
Fiscal Year: 2016
Project Start Date: 1 August 2016
Project End Date: 30 June 2021
Project program: Multi-Year Funded Research Project Grant
 
Project Funding Information:
Funding Mechanism: Non-SBIR/STTR RPGs
Year Funding Organization Total Funding, $
2016 NIH - National Institute On Aging $8,800,813
Project Title: Genetic epidemiology of cerebrovascular factors in alzheimer's disease
Project Number: 1RF1AG054023-01
Project web address: Follow on NIH
Organization: Columbia University Health Sciences, United States, New York, NEW YORK
Principal Investigators (PI): Mayeux Richard, US
 
Title FY Funding
There are no results for this project in database.
Project Title: Genetic epidemiology of cerebrovascular factors in alzheimer's disease
Project Number: 1RF1AG054023-01
Project web address: Follow on NIH
Organization: Columbia University Health Sciences, United States, New York, NEW YORK
Principal Investigators (PI): Mayeux Richard, US
 
Project Title Organization FY Funding
Genetic Epidemiology Of Cerebrovascular Factors In Alzheimer'S DiseaseColumbia University Health Sciences2016$8,800,813
Project Title: Genetic epidemiology of cerebrovascular factors in alzheimer's disease
Project Number: 1RF1AG054023-01
Project web address: Follow on NIH
Organization: Columbia University Health Sciences, United States, New York, NEW YORK
Principal Investigators (PI): Mayeux Richard, US
 
Project number Project title Principal investigator
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Project Title: Genetic epidemiology of cerebrovascular factors in alzheimer's disease
Project Number: 1RF1AG054023-01
Project web address: Follow on NIH
Organization: Columbia University Health Sciences, United States, New York, NEW YORK
Principal Investigators (PI): Mayeux Richard, US
 
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