Lifecourse health, cerebral pathology and ethnic disparities in dementia

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Project Title: Lifecourse health, cerebral pathology and ethnic disparities in dementia
Project Number: 1RF1AG052132-01
Project web address: Follow on NIH
Organization: Kaiser Foundation Research Institute, United States, California, LOS ANGELES
Principal Investigators (PI): Whitmer Rachel A, US
Decarli Charles, US
Glymour Medellena Maria, US
Mungas Dan M, US
 
Project Description:
A primary objective of the 2012 National Alzheimer's Plan Act was to decrease racial disparities of dementia. While it is known that certain ethnoracial groups such as Blacks have higher rates of dementia, reasons for disparities are unknown. The NIH State of the Science on Preventing Cognitive Decline recommended a life course approach to identifying modifiable risk and protective factors. Whether early life factors contribute to ethnic disparities in dementia and cognitive decline and how these variables relate to brain changes that may mediate disparities is not well understood. Further, effects of risk and protective factors may vary across ethnoracial groups. Most of what is known about risk and protective factors and brain mechanisms for dementia is from studies of non-Hispanic whites. We propose an unprecedented lifecourse study of disparities in late life cognitive decline and dementia using a large multi-ethnoracial sample of current Kaiser Permanente health system members who participated in the Multiphasic Health Study (MHS) extending from 1964-1991. MHS data, joined with electronic medical records from 1996-present, provide up to 50 years of comprehensive, prospectively collected data. Eighteen hundred (450 Black, 450 Hispanic, 450 White, 450 Asian) MHS participants aged 65+ will receive cognitive and clinical evaluations at 3 time points to rigorously characterize prevalence and incidence of dementia and measure cognitive decline using well-validated tests for ethnoracially diverse older adults. Structural MRI and Amyloid PET will be obtained on a random sub sample of 400 non-demented individuals to characterize cerebral amyloid burden, vascular lesions, and neuronal injury (atrophy). Our objectives are to delineate why there are racial/ethnic disparities in dementia and how life course risk and protective factors and brain mechanisms differ across ethnoracial groups. We will do so with three Specific Aims: 1) Evaluate ethnoracial differences in dementia incidence and cognitive decline, 2) Evaluate how early life experience, life course health, and genetics influence ethnoracial differences in cognitive decline and dementia, 3) Characterize paths by which ethnicity/race and cumulative vascular risk influence brain status (amyloid, vascular brain injury, atrophy) and cognitive decline.
 
Project Terms:
accounting ad pathology age aged aging population alzheimer's disease americas amyloid apolipoprotein e asians atrophic blood vessels brain cerebral atrophy cerebrovascular trauma cerebrum cognitive cohort computerized medical record cost effective data dementia diabetes mellitus diagnosis elderly emerging adult enrollment ethnic disparity ethnic origin exposure to future genetic growth health health data health system hispanics hyperlipidemia hypertension impaired cognition incidence individual insight knowledge latino lead lesion life life cycle stages life experience life history longitudinal studies magnetic resonance imaging measures mediating member minority modifiable risk natural experiment neuronal injury non-demented not hispanic or latino obesity outcome participant pathology positron-emission tomography prevalence prevent prevention prevention strategy primary prevention public health relevance race racial and ethnic disparities racial disparity research clinical testing resources risk risk factors role sampling science socioeconomic status testing time treatment strategy united states national institutes of health variant young adult acquired cognitive impairment aging alzheimer's disease including alzheimer's disease related dementias (ad/adrd) behavioral and social science brain disorders cerebrovascular clinical research neurodegenerative neurosciences
Project Title: Lifecourse health, cerebral pathology and ethnic disparities in dementia
Project Number: 1RF1AG052132-01
Project web address: Follow on NIH
Organization: Kaiser Foundation Research Institute, United States, California, LOS ANGELES
Principal Investigators (PI): Whitmer Rachel A, US
Decarli Charles, US
Glymour Medellena Maria, US
Mungas Dan M, US
 
Project Categories:
Natural Sciences
 
Other Information:
Fiscal Year: 2016
Project Start Date: 1 June 2016
Project End Date: 31 May 2021
Project program: Multi-Year Funded Research Project Grant
 
Project Funding Information:
Funding Mechanism: Non-SBIR/STTR RPGs
Year Funding Organization Total Funding, $
2016 NIH - National Institute On Aging $13,078,633
Project Title: Lifecourse health, cerebral pathology and ethnic disparities in dementia
Project Number: 1RF1AG052132-01
Project web address: Follow on NIH
Organization: Kaiser Foundation Research Institute, United States, California, LOS ANGELES
Principal Investigators (PI): Whitmer Rachel A, US
Decarli Charles, US
Glymour Medellena Maria, US
Mungas Dan M, US
 
Title FY Funding
There are no results for this project in database.
Project Title: Lifecourse health, cerebral pathology and ethnic disparities in dementia
Project Number: 1RF1AG052132-01
Project web address: Follow on NIH
Organization: Kaiser Foundation Research Institute, United States, California, LOS ANGELES
Principal Investigators (PI): Whitmer Rachel A, US
Decarli Charles, US
Glymour Medellena Maria, US
Mungas Dan M, US
 
Project Title Organization FY Funding
Lifecourse Health, Cerebral Pathology And Ethnic Disparities In DementiaKaiser Foundation Research Institute2016$13,078,633
Project Title: Lifecourse health, cerebral pathology and ethnic disparities in dementia
Project Number: 1RF1AG052132-01
Project web address: Follow on NIH
Organization: Kaiser Foundation Research Institute, United States, California, LOS ANGELES
Principal Investigators (PI): Whitmer Rachel A, US
Decarli Charles, US
Glymour Medellena Maria, US
Mungas Dan M, US
 
Project number Project title Principal investigator
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Project Title: Lifecourse health, cerebral pathology and ethnic disparities in dementia
Project Number: 1RF1AG052132-01
Project web address: Follow on NIH
Organization: Kaiser Foundation Research Institute, United States, California, LOS ANGELES
Principal Investigators (PI): Whitmer Rachel A, US
Decarli Charles, US
Glymour Medellena Maria, US
Mungas Dan M, US
 
Title Journal Year Country Rel